PCL 04 - Pathophysiology of Tendinopathy (Mamie)

Overloading crucial in development

Generally occurs near the insertion of a muscle where there is non-uniform strain on tendons and areas of stress concentration develops

No inflammation but initiators of tendinopathic pathway include proinflammatory agents such as cytokines, prostaglandins, growth factors and neuropathies
http://www3.interscience.wiley.com.ezproxy.lib.monash.edu.au/journal/119407081/abstract?CRETRY=1&SRETRY=0)

Histology - cells are
Rounder
More numerous
Abnormal regulation of apoptosis (most apoptotic cells identified as fibroblasts or fibroblast-like)
More evidence of oxidative damage
Abnormally plentiful tenocytes (often with alterations in size and shape of mitochondria and nucleus)

Histology - matrix is
Collagen degeneration
Thicker
Weaker
Higher water content
More immature, cartilage-like proteins
Less organised/disoriented fibres


http://www.mdconsult.com.ezproxy.lib.monash.edu.au/das/article/body/101401106-2/jorg=journal&source=&sp=14064019&sid=0/N/378936/1.html?issn=0278-5919

http://web.ebscohost.com.ezproxy.lib.monash.edu.au/ehost/detail?vid=1&hid=16&sid=dcb275f3-624c-407c-be23-008fabaf040c%40sessionmgr2&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=s3h&AN=15226347

http://www.springerlink.com.ezproxy.lib.monash.edu.au/content/g47505280228587w/

http://www3.interscience.wiley.com.ezproxy.lib.monash.edu.au/journal/119407081/abstract?CRETRY=1&SRETRY=0

Diagram: http://www.mdconsult.com.ezproxy.lib.monash.edu.au/das/article/body/101408767-2/jorg=journal&source=&sp=14064019&sid=0/N/378936/I9.fig