Wednesday, July 23, 2008

Pathophysiology of Tiger Snake Venom

Neurotoxins: (Pre-synaptic and post-synaptic)
- cause paralysis or muscle weakness
- pre-synaptic: slow onset, irreversible, only respond to antivenom if given early
- post-synaptic: rapid onset, reversible, respond to anticholinesterases and antivenom

Myotoxins:
- cause muscle damage (myolysis)

Procoagulants:
- interfere with blood clotting by consuming fibrinogen, causing defibrination, which puts the victim at risk of major bleeding

References:

http://www.toxinology.com/about/tiger_snake_snakebite.html
Lecture 15: Envenomation (W. Hodgson)

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